Studies of the metal binding properties and DNA recognition mode of the unusual zinc fingers in poly(ADP-ribose) Polymerase-1 and the investigation of its interaction with apoptosis inducing factor (AIF)
Poly(ADP-ribosyl)ation, a covalent modification of proteins catalyzed by poly(ADP-ribose) polymerases (PARPs), plays a crucial role in regulating DNA repair, DNA replication, and cell death. Poly(ADP-ribose) Polymerase-1 (PARP-1) is a nuclear zinc-finger DNA-binding protein that is the most extensiv...
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| Format: | Others |
| Language: | English |
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2013
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| Online Access: | http://hdl.handle.net/2152/21906 |