Conformational dynamics plays a significant role in HIV reverse transcriptase resistance and substrate selection
Human immunodeficiency virus reverse transcriptase (HIV RT) is a virally encoded polymerase responsible for replicating the HIV genome. Most HIV treatments include nucleotide RT inhibitors (NRTIs) which inhibit HIV RT replication by serving as a substrate for the polymerase reaction but then blocks...
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| Format: | Others |
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2014
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| Online Access: | http://hdl.handle.net/2152/23876 |