Rhodopsin kinase structure: different nucleotide-binding states and implications for mechanism of activation of a G protein coupled receptor kinase

Rhodopsin kinase structure: different nucleotide-binding states and implications for mechanism of activation of a G protein coupled receptor kinase

G protein coupled receptor (GPCR) kinases (GRKs) phosphorylate activated heptahelical receptors, leading to their uncoupling from G proteins and downregulation. The desensitization of GPCRs is critical to render cells responsive to further stimuli and if not regulated can result in many pathophysiol...

Full description

Bibliographic Details
Main Author: Singh, Puja, 1979-
Other Authors: Tesmer, John
Format: Others
Language:English
Published: 2008
Subjects:
Protein kinases
Rhodopsin
G proteins
Cell receptors
Phosphorylation
Nucleotides
Online Access:http://hdl.handle.net/2152/3691

Internet

http://hdl.handle.net/2152/3691

Similar Items