Design, synthesis, and evaluation of conformationally-constrained Grb2 SH2 ligands and a concise total synthesis of lycopladine A

Design, synthesis, and evaluation of conformationally-constrained Grb2 SH2 ligands and a concise total synthesis of lycopladine A

Conformationally constrained ligands and their flexible analogues were prepared as inhibitors of the Grb2 SH2 domain in order to study the structural and energetic effects of ligand preorganization in protein-ligand interactions. The compounds were prepared by using trans-cyclopropane-containing am...

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Bibliographic Details
Main Author: Delorbe, Johnathan E.
Format: Others
Language:English
Published: 2010
Subjects:
Peptide synthesis
Protein-ligand binding
Protein-ligand crystallography
Natural product total synthesis
Grb2 SH2 ligands
Ligands
Lycopladine A
Online Access:http://hdl.handle.net/2152/ETD-UT-2010-05-795

Internet

http://hdl.handle.net/2152/ETD-UT-2010-05-795

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