Structural and Biochemical Studies of Alkylpurine DNA Glycosylase AlkD
Alkylating agents covalently modify DNA bases to generate a chemically diverse set of lesions including cytotoxic N3-methyladenine (3mA) bases and mutagenic 1,N6-ethenoadenine (εA) and N7-methylguanine (7mG). To maintain genomic integrity, these lesions are repaired by the base excision repair pathw...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2011
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-02162011-143438/ |