Mechanisms of glucagon secretion in mouse pancreatic alpha-cells

Under hypoglycemic conditions, glucagon is secreted from α-cells, within pancreatic islets of Langerhans, to stimulate hepatic glucose output and, therefore, to restore proper glycemia. Once normoglycemia is reestablished, glucagon release is inhibited. Two general models have been proposed to accou...

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Bibliographic Details
Main Author: Le Marchand, Sylvain
Other Authors: Owen McGuinness
Format: Others
Language:en
Published: VANDERBILT 2011
Subjects:
Online Access:http://etd.library.vanderbilt.edu/available/etd-02212011-191009/