Effects of DNA Geometry and Topoisomerase II Poisons on Human and Bacterial Type II Topoisomerases
The topological state of DNA has a dramatic effect on nucleic acid processes in cells. Type II topoisomerases are necessary enzymes that help regulate the topological state of the genome, but their activity requires the creation of transient DNA breaks. This potential to induce DNA damage is exploit...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | en |
| Published: |
VANDERBILT
2017
|
| Subjects: | |
| Online Access: | http://etd.library.vanderbilt.edu/available/etd-03062017-124217/ |