Bruton's typrosine kinase and autoreactive B lymphocytes: Roles in development, survival, and disease
Brutonâs tyrosine kinase (BTK) is a tec-family kinase present in B lymphocytes and innate immune cells. BTK is an important regulator of B cell autoreactivity. Innate-like autoreactive-prone B1, anergic An1, and transgenic anti-insulin B cells all rely upon BTK. Autoreactive B cells drive Type 1 dia...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2017
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-03222017-135307/ |