Hydrophobic Modification of siRNA to Improve Delivery and Efficacy of RNAi Therapeutics
Small interfering RNA (siRNA) can potently and specifically suppress translation of any gene, including intracellular targets traditionally considered âundruggableâ. However, emergence of translational siRNA therapies has remained slow, with the primary challenge being the formidable anatomical and...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2017
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-03272017-155710/ |