LONG-TERM SMOKING-MEDIATED DOWNREGULATION OF SMAD3 INDUCES TUMORIGENICITY AND CARBOPLATIN RESISTANCE IN NON-SMALL CELL LUNG CANCER
Inactivating mutations in TGF-©¬ receptors and Smad signal transducers that contribute to resistance to TGF-©¬, are associated with only very small number of NSCLC. The Smad dependent pathway is involved in the tumor suppressive functions of TGF-¥â. Epidemiological studies have demonstrated that mos...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2012
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-04122012-114031/ |