A Comparison of Approaches for Unplanned Sample Size Changes in Phase II Clinical Trials
Oncology phase II clinical trials are used to evaluate the initial effect of a new regimen to determine if there warrants further study in a phase III clinical trial. Two-stage designs with an early futility stop are commonly used in these phase II trials. It is common for attained sample sizes in t...
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| Language: | en |
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VANDERBILT
2017
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-06132017-150729/ |