Application of Organocatalysis to the Synthesis of Pharmaceutically Relevant Scaffolds: Chiral Aziridines and β-Fluoroamines; Total Synthesis of Stemaphylline; and Discovery of Selective PAR4 Antagonists.
Aziridines represent an important class of nitrogen-containing heterocycles with a wide range of synthetic utility. Despite their value, synthetic approaches are limited in terms of generality and diversity. On this basis, we developed a three step, one-pot protocol involving enantioselective α-chlo...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | en |
| Published: |
VANDERBILT
2013
|
| Subjects: | |
| Online Access: | http://etd.library.vanderbilt.edu/available/etd-07192013-164751/ |