Structural and functional analysis of Clostridium difficile toxins A and B
The pathogenesis of Clostridium difficile is dependent on two large homologous toxins, TcdA and TcdB. These toxins contain glucosyltransferase domains that inactivate host Rho proteins by glucosylation. Delivery of the glucosyltransferase domain into the target cell is achieved by binding to the tar...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2011
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| Online Access: | http://etd.library.vanderbilt.edu//available/etd-09122011-113740/ |