FUNCTIONAL ANNOTATION OF ORPHAN HUMAN P450 ENZYMES: HETEROLOGOUS EXPRESSION AND SUBSTRATE SEARCHES BY METABOLOMIC APPROACHES
Cytochrome P450s are versatile biocatalysts that play crucial roles in many important biological processes. Functional annotation of orphan P450 enzymes is the focus of this work. Catalytic activities of orphan human P450 2S1, 2W1, and 4X1 were investigated with untargeted metabolomic approaches. A...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2014
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-09152014-151801/ |