AUTOREACTIVE B CELL DEVELOPMENT IN THE PERIPHERY
Self-reactive B lymphocytes are frequently produced as a consequence of B cell antigen receptor rearrangement. Autoreactive B cells that are not eliminated or inactivated by tolerance mechanisms survive and mature in the periphery. In the spleen, the marginal zone serves as a reservoir for autoreact...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2006
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-09182006-172759/ |