BASOPHILE: ACCURATE FRAGMENT CHARGE STATE PREDICTION IMPROVES PEPTIDE IDENTIFICATION RATES
In shotgun proteomics, database search algorithms rely on fragmentation models to predict fragment ions that should be observed for a given peptide sequence. The most widely used strategy (Naïve model) is oversimplified, breaking all peptide bonds with equal probability to produce fragments of all c...
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| Language: | en |
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VANDERBILT
2012
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-10302012-183017/ |