NGN3-EXPRESSING PROGENITOR HETEROGENEITY DRIVES ENDOCRINE LINEAGE ALLOCATION IN PANCREAS DEVELOPMENT

Diabetes is a worldwide health issue. In both type I and late stage type II diabetes, significant beta-cell loss causes insulin deficiency and hyperglycemia. Replenishing beta cells is a promising therapy and it requires enhancing beta-cell replication, activating a beta-cell neogenesis program or t...

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Bibliographic Details
Main Author: Liu, Jing
Other Authors: Mark Magnuson
Format: Others
Language:en
Published: VANDERBILT 2015
Subjects:
Online Access:http://etd.library.vanderbilt.edu/available/etd-11152015-162440/