Immunomodulation of Tumor Associated Macrophages by Targeted, siRNA-Delivering Nanoparticles

Tumor associated macrophages (TAMs) play an important role in establishing a pro-tumor environment in many tumor types. Produce low levels of inflammatory cytokines which creates pro-tumorigenic smoldering inflammation and also TAMs break down the surrounding extracellular matrix, secrete growth fac...

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Bibliographic Details
Main Author: Ortega, Ryan Adam
Other Authors: Todd D. Giorgio
Format: Others
Language:en
Published: VANDERBILT 2014
Subjects:
Online Access:http://etd.library.vanderbilt.edu/available/etd-11232014-110428/