A Reductionist Study into the Physiology, Pathology, and Pharmacology of the Mitotic Spindle
Mitotic kinesins represent the new age targets of spindle-poisoning chemotherapies. The kinesin-5 Eg5 is one such example, as kinesin-5 inhibitors (K5Is) induce a lethal mitotic arrest from failed spindle assembly. Documented here is the discovery of a novel spindle assembly pathway that confers K5I...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | en |
| Published: |
VANDERBILT
2014
|
| Subjects: | |
| Online Access: | http://etd.library.vanderbilt.edu/available/etd-11242014-142447/ |