Studies Toward the Total Synthesis of HMP-Y1 and Hibarimicinone
The hibarimicin family of natural products was isolated in 1995 from the culture broth of the rare actinomycete Microbispora rosea subsp. hibaria TP-A0121. This complex polyketide type II family exhibits strong inhibition of src tyrosine kinase (IC50 = 580 nM to 2.32 µM), and hibarimicin B exhibited...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | en |
| Published: |
VANDERBILT
2012
|
| Subjects: | |
| Online Access: | http://etd.library.vanderbilt.edu/available/etd-12212012-101204/ |