Syntheses and Bioactivities of Targeted and Conformationally Restrained Taxol Analogs
Taxol (1) was first isolated from the bark of the Pacific yew about 35 years ago by Drs. Wall and Wani. Although its development as an anticancer agent was delayed by numerous reasons, including its scarcity and insolubility, the discovery of its tubulin-assembly activity and other factors motivated...
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Virginia Tech
2011
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| Online Access: | http://hdl.handle.net/10919/11186 http://scholar.lib.vt.edu/theses/available/etd-05182004-172743 |