Developmental Regulation of Prion Expression in Cattle and Mouse Embryonic Stem Cells

Developmental Regulation of Prion Expression in Cattle and Mouse Embryonic Stem Cells

The host encoded cellular prion protein (PrPC) is an N-linked glycoprotein tethered to the cell membrane by a glycophosphatidylinositol (GPI) anchor. Under certain conditions, PrPC can undergo conversion into a conformationally-altered isoform (PrPSc) widely believed to be the pathogenic agent of tr...

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Bibliographic Details
Main Author: Peralta, Oscar A.
Other Authors: Veterinary Medical Sciences
Format: Others
Published: Virginia Tech 2014
Subjects:
Somatic tissues
Reproductive tract
Prion gene (Prnp)
Cellular prion protein (PrPC)
Embryogenesis
Gene expression
Embryonic stem cells
Neural differentiation
Online Access:http://hdl.handle.net/10919/28584
http://scholar.lib.vt.edu/theses/available/etd-08092008-165032/

Internet

http://hdl.handle.net/10919/28584
http://scholar.lib.vt.edu/theses/available/etd-08092008-165032/

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