Mechanistic Studies on Memory of Chirality Alkylations of 1,4-Benzodiazepin-2-ones & Structure-based Design of Insecticidal AChE Inhibitors for Malaria Mosquito, Anopheles gambiae

Mechanistic Studies on Memory of Chirality Alkylations of 1,4-Benzodiazepin-2-ones & Structure-based Design of Insecticidal AChE Inhibitors for Malaria Mosquito, Anopheles gambiae

Memory of chirality (MOC) is an emerging strategy for asymmetric synthesis which relies upon the intermediacy of transiently non-racemic reactive species. In these reactions the configuration of the sole stereogenic center of the enantiopure starting material is "memorized" by a chiral non...

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Bibliographic Details
Main Author: Hsu, Danny Chung
Other Authors: Chemistry
Format: Others
Published: Virginia Tech 2014
Subjects:
Asymmetric Synthesis
Memory of Chirality
Anopheles gambiae
Sulfhydryl Reagents
Free Cysteine Targeting
Acetylcholinesterase
Kinetics
Freeze Frame Observation
Enolate Chemistry
1 4-Benzodiazepin-2-one
Density Functional Theory
Online Access:http://hdl.handle.net/10919/29192
http://scholar.lib.vt.edu/theses/available/etd-10042007-161139/

Internet

http://hdl.handle.net/10919/29192
http://scholar.lib.vt.edu/theses/available/etd-10042007-161139/

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