Studies of Bioactive Natural Products and Mechanism-Based Bioassays

An extract of the sponge <i>Rhabdastrella globostellifera</i> was active in an assay measuring stabilization of the binding of DNA with DNA polymerase &beta;. From this extract, four isomalabaricane triterpenoids were isolated and characterized, three of which were active in the bin...

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Bibliographic Details
Main Author: Clement, Jason Anderson
Other Authors: Chemistry
Format: Others
Published: Virginia Tech 2014
Subjects:
Online Access:http://hdl.handle.net/10919/29879
http://scholar.lib.vt.edu/theses/available/etd-12022005-160735/