Design and Synthesis of Novel Benzodiazepines

Design and Synthesis of Novel Benzodiazepines

Bivalent drug design is an efficient strategy for increasing potency and selectivity of many drugs. We devised a strategy to prepare agonist-benzodiazepine heterodimers that could simultaneously bind to agonist and BZD sites of the GABAAR. We synthesized a benzodiazepine-MPEG model compound that rel...

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Bibliographic Details
Main Author: MacQuarrie, Stephanie Lee
Other Authors: Chemistry
Format: Others
Published: Virginia Tech 2014
Subjects:
4-Benzodiazepin-1
5-dione
Density Functional Theory
Memory of Chirality
Agonist
Asymmetric Synthesis
1
Benzodiazepine
Bivalent Ligand
GABAA Receptor
Heterodimer
Online Access:http://hdl.handle.net/10919/30209
http://scholar.lib.vt.edu/theses/available/etd-12212005-223136/

Internet

http://hdl.handle.net/10919/30209
http://scholar.lib.vt.edu/theses/available/etd-12212005-223136/

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