Radical cyclization approach to a chemoenzymatic synthesis of morphine
A three component, convergent synthesis of the isoquinoline alkaloid morphine was designed which incorporated the ten-membered silicon-containing epoxide [figure 1], the diene diol [figure 2], and the known oxazolone [figure 3]. See: Figures 1, 2, and 3 Diene diol [figure 2] was isolated in the a...
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| Format: | Others |
| Language: | en |
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Virginia Tech
2014
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| Online Access: | http://hdl.handle.net/10919/40215 http://scholar.lib.vt.edu/theses/available/etd-10262005-143517/ |