REAL-TIME OBSERVATION OF MOLECULAR REACTION MECHANISM OF HALOPYRIMIDINES AS RADIO-/PHOTOSENSITIZING DRUGS USING TIME-RESOLVED FEMTOSECOND LASER SPECTROSCOPY

REAL-TIME OBSERVATION OF MOLECULAR REACTION MECHANISM OF HALOPYRIMIDINES AS RADIO-/PHOTOSENSITIZING DRUGS USING TIME-RESOLVED FEMTOSECOND LASER SPECTROSCOPY

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Replacement of thymidine in DNA by halopyrimidines, such as bromodeoxyuridine (BrdU) and iododeoxyuridine (IdU), has long been known to enhance DNA damage and cell death induced by ionizing/UV radiation, but the mechanism of action of halopyrimidines at the molecular level is poorly understood. We h...

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Bibliographic Details
Main Author: Wang, Chunrong
Format: Others
Language:en
Published: 2007
Subjects:
femtochemistry&femtobiology
electron transfer
dissociative attachment of electrons
radiotherapy
reactive intermediates
molecular reaction mechanisms
Physics
Online Access:http://hdl.handle.net/10012/3067

Internet

http://hdl.handle.net/10012/3067

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