Investigations of the Natural Product Antibiotic Thiostrepton from Streptomyces azureus and Associated Mechanisms of Resistance

Investigations of the Natural Product Antibiotic Thiostrepton from Streptomyces azureus and Associated Mechanisms of Resistance

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The persistence and propagation of bacterial antibiotic resistance presents significant challenges to the treatment of drug resistant bacteria with current antimicrobial chemotherapies, while a dearth in replacements for these drugs persists. The thiopeptide family of antibiotics may represent a pot...

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Bibliographic Details
Main Author: Myers, Cullen Lucan
Language:en
Published: 2013
Subjects:
thiostrepton
ribosome
antibiotics
antibiotic resistance
methyltransferase
site-directed mutagenesis
S-Adenosyl-L-methionine
enzymology
semi-synthesis
isothermal titration calorimetry
thiostrepton derivatives
AdoMet analogue
Chemistry
Online Access:http://hdl.handle.net/10012/7381

Internet

http://hdl.handle.net/10012/7381

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