Directed Evolution of a Beta-Sheet Scaffold for Targeting Proteins Involved in Human Disease - Thrombin and the Vascular Endothelial Growth Factor (VEGF)
Aberrant protein-protein interactions have been implicated in numerous human diseases. Hence it becomes important to understand the physicochemical basis of these interactions as well as to develop methods to selectively target these protein surfaces. However, it is difficult to target such protein...
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| Language: | EN |
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The University of Arizona.
2007
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| Online Access: | http://hdl.handle.net/10150/194401 |