DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage

DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage

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BACKGROUND:Hypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epithelial cancers.METHODS:The methylation of 6,502 CpG-rich sequences spanning the...

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Bibliographic Details
Main Authors: Watts, George, Futscher, Bernard, Holtan, Nicholas, DeGeest, Koen, Domann, Frederick, Rose, Stephen
Other Authors: Department of Medical Pharmacology, College of Medicine, University of Arizona, Tucson AZ 85724 USA
Language:en
Published: BioMed Central 2008
Online Access:http://hdl.handle.net/10150/610037
http://arizona.openrepository.com/arizona/handle/10150/610037

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http://hdl.handle.net/10150/610037
http://arizona.openrepository.com/arizona/handle/10150/610037

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