Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain

Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain

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BACKGROUND:Mechanisms driving cancer-induced bone pain are poorly understood. A central factor implicated to be a key player in the process of tumorigenesis, osteoclastogenesis and nociception is p38 MAPK. We determined the role of p38 MAPK in a mouse model of breast cancer induced bone pain in whic...

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Bibliographic Details
Main Authors: Sukhtankar, Devki, Okun, Alec, Chandramouli, Anupama, Nelson, Mark, Vanderah, Todd, Cress, Anne, Porreca, Frank, King, Tamara
Other Authors: Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
Language:en
Published: BioMed Central 2011
Online Access:Sukhtankar et al. Molecular Pain 2011, 7:81 http://www.molecularpain.com/content/7/1/81
http://hdl.handle.net/10150/610213
http://arizona.openrepository.com/arizona/handle/10150/610213

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Sukhtankar et al. Molecular Pain 2011, 7:81 http://www.molecularpain.com/content/7/1/81
http://hdl.handle.net/10150/610213
http://arizona.openrepository.com/arizona/handle/10150/610213

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