Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene

BACKGROUND: Nemaline myopathy (NM), the most common non-dystrophic congenital myopathy, is characterized by generalized skeletal muscle weakness, often from birth. To date, no therapy exists that enhances the contractile strength of muscles of NM patients. Mutations in NEB, encoding the giant protei...

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Bibliographic Details
Main Authors: de Winter, J. M., Joureau, B., Sequeira, V., Clarke, N. F., van der Velden, J., Stienen, G. J., Granzier, H., Beggs, A. H., Ottenheijm, C. A.
Other Authors: Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center Amsterdam
Language:en
Published: BioMed Central 2015
Subjects:
Calcium-sensitizer
Levosimendan
Muscle force
Muscle mechanics
Nebulin
Nemaline myopathy
Online Access:http://hdl.handle.net/10150/610333
http://arizona.openrepository.com/arizona/handle/10150/610333

Internet

http://hdl.handle.net/10150/610333
http://arizona.openrepository.com/arizona/handle/10150/610333

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