Engineering of N. benthamiana L. plants for production of N-acetylgalactosamine-glycosylated proteins - towards development of a plant-based platform for production of protein therapeutics with mucin type O-glycosylation

Engineering of N. benthamiana L. plants for production of N-acetylgalactosamine-glycosylated proteins - towards development of a plant-based platform for production of protein therapeutics with mucin type O-glycosylation

BACKGROUND:Mucin type O-glycosylation is one of the most common types of post-translational modifications that impacts stability and biological functions of many mammalian proteins. A large family of UDP-GalNAc polypeptide:N-acetyl-alpha-galactosaminyltransferases (GalNAc-Ts) catalyzes the first ste...

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Bibliographic Details
Main Authors: Daskalova, Sasha, Radder, Josiah, Cichacz, Zbigniew, Olsen, Sam, Tsaprailis, George, Mason, Hugh, Lopez, Linda
Other Authors: Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
Language:en
Published: BioMed Central 2010
Online Access:Daskalova et al. BMC Biotechnology 2010, 10:62 http://www.biomedcentral.com/1472-6750/10/62
http://hdl.handle.net/10150/610340
http://arizona.openrepository.com/arizona/handle/10150/610340

Internet

Daskalova et al. BMC Biotechnology 2010, 10:62 http://www.biomedcentral.com/1472-6750/10/62
http://hdl.handle.net/10150/610340
http://arizona.openrepository.com/arizona/handle/10150/610340

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