Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer

Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer

BACKGROUND:The glycolytic nature of malignant tumors contributes to high levels of extracellular acidity in the tumor microenvironment. Tumor acidity is a driving force in invasion and metastases. Recently, it has been shown that buffering of extracellular acidity through systemic administration of...

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Bibliographic Details
Main Authors: Robey, Ian, Martin, Natasha
Other Authors: Arizona Respiratory Center, University of Arizona, Tucson Arizona, USA
Language:en
Published: BioMed Central 2011
Subjects:
Tumor
pH
Acidity
Dichloroacetate
Sodium bicarbonate
Online Access:Robey and Martin BMC Cancer 2011, 11:235 http://www.biomedcentral.com/1471-2407/11/235
http://hdl.handle.net/10150/610344
http://arizona.openrepository.com/arizona/handle/10150/610344

Internet

Robey and Martin BMC Cancer 2011, 11:235 http://www.biomedcentral.com/1471-2407/11/235
http://hdl.handle.net/10150/610344
http://arizona.openrepository.com/arizona/handle/10150/610344

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