The Effects of the Insulin Signaling Pathway on TDP-43 Neurotoxicity in Amyotrophic Lateral Sclerosis
The causes of Amyotrophic Lateral Sclerosis (ALS), a fatal neurodegenerative disease that results in skeletal muscle paralysis, remain unclear. However, a nuclear DNA and RNA binding protein called TAR DNA binding protein 43 (TDP-43) has emerged as a critical marker of ALS pathology. A previous drug...
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| Language: | en_US |
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The University of Arizona.
2016
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| Online Access: | http://hdl.handle.net/10150/613411 http://arizona.openrepository.com/arizona/handle/10150/613411 |