The small GTPases Ras and Rap1 bind to and control TORC2 activity

The small GTPases Ras and Rap1 bind to and control TORC2 activity

Target of Rapamycin Complex 2 (TORC2) has conserved roles in regulating cytoskeleton dynamics and cell migration and has been linked to cancer metastasis. However, little is known about the mechanisms regulating TORC2 activity and function in any system. In Dictyostelium, TORC2 functions at the fron...

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Bibliographic Details
Main Authors: Khanna, Ankita, Lotfi, Pouya, Chavan, Anita J., Montaño, Nieves M., Bolourani, Parvin, Weeks, Gerald, Shen, Zhouxin, Briggs, Steven P., Pots, Henderikus, Van Haastert, Peter J. M., Kortholt, Arjan, Charest, Pascale G.
Other Authors: Univ Arizona, Dept Chem & Biochem
Language:en
Published: NATURE PUBLISHING GROUP 2016
Subjects:
CONTROLS CELL-ADHESION
DICTYOSTELIUM-DISCOIDEUM
SIGNAL RELAY
MACROPHAGES PROMOTE
MEDIATED ACTIVATION
ACTIN CYTOSKELETON
PARACRINE LOOP
G-PROTEINS
CHEMOTAXIS
MIGRATION
Online Access:http://hdl.handle.net/10150/614747
http://arizona.openrepository.com/arizona/handle/10150/614747

Internet

http://hdl.handle.net/10150/614747
http://arizona.openrepository.com/arizona/handle/10150/614747

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