Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir.

Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir.

Adefovir, an acyclic nucleotide reverse transcriptase inhibitor used to treat hepatitis B viral infection, is primarily eliminated renally through cooperation of glomerular filtration with active tubular transport. Nonalcoholic steatohepatitis is a variable in drug disposition, yet the impact on ren...

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Bibliographic Details
Main Authors: Laho, Tomas, Clarke, John D, Dzierlenga, Anika L, Li, Hui, Klein, David M, Goedken, Michael, Micuda, Stanislav, Cherrington, Nathan J
Other Authors: Univ Arizona, Dept Pharmacol & Toxicol
Language:en
Published: PERGAMON-ELSEVIER SCIENCE LTD 2016
Subjects:
Adefovir
GFR
NASH
Renal elimination
Online Access:http://hdl.handle.net/10150/621211
http://arizona.openrepository.com/arizona/handle/10150/621211

Internet

http://hdl.handle.net/10150/621211
http://arizona.openrepository.com/arizona/handle/10150/621211

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