miR‐17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia‐Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation

miR‐17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia‐Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation

Background-Previously we found that smooth muscle cell (SMC)-specific knockout of miR-17 similar to 92 attenuates hypoxia-induced pulmonary hypertension. However, the mechanism underlying miR-17 similar to 92-mediated pulmonary artery SMC (PASMC) proliferation remains unclear. We sought to investiga...

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Bibliographic Details
Main Authors: Chen, Tianji, Zhou, Qiyuan, Tang, Haiyang, Bozkanat, Melike, Yuan, Jason X.‐J., Raj, J. Usha, Zhou, Guofei
Other Authors: Univ Arizona, Dept Med
Language:en
Published: WILEY-BLACKWELL 2016
Subjects:
hypoxia
hypoxia-inducible factor 1
miR-17(similar to)92
prolyl hydroxylase 2
pulmonary artery smooth muscle cell
pulmonary hypertension
smooth muscle cell
Online Access:http://hdl.handle.net/10150/622697
http://arizona.openrepository.com/arizona/handle/10150/622697

Internet

http://hdl.handle.net/10150/622697
http://arizona.openrepository.com/arizona/handle/10150/622697

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