Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

Background: Carriers of the APOE epsilon 4 allele are at increased risk of developing Alzheimer's disease (AD), and have been shown to have reduced cerebral metabolic rate of glucose (CMRgl) in the same brain areas frequently affected in AD. These individuals also exhibit reduced plasma levels...

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Bibliographic Details
Main Authors: Nielsen, Henrietta M., Chen, Kewei, Lee, Wendy, Chen, Yinghua, Bauer, Robert J., Reiman, Eric, Caselli, Richard, Bu, Guojun
Other Authors: Univ Arizona, Dept Psychiat
Language:en
Published: BIOMED CENTRAL LTD 2017
Subjects:
Apolipoprotein E
Dementia
Plasma
Cognition
Gray matter volume
Online Access:http://hdl.handle.net/10150/622812
http://arizona.openrepository.com/arizona/handle/10150/622812

Internet

http://hdl.handle.net/10150/622812
http://arizona.openrepository.com/arizona/handle/10150/622812

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