Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA

RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of lon...

Full description

Bibliographic Details
Main Authors:	Weldon, Carika, Behm-Ansmant, Isabelle, Hurley, Laurence H, Burley, Glenn A, Branlant, Christiane, Eperon, Ian C, Dominguez, Cyril
Other Authors:	College of Pharmacy and BIO5 Institute, University of Arizona
Language:	en
Published:	NATURE PUBLISHING GROUP 2016
Online Access:	http://hdl.handle.net/10150/623077 http://arizona.openrepository.com/arizona/handle/10150/623077

id	ndltd-arizona.edu-oai-arizona.openrepository.com-10150-623077
record_format	oai_dc
spelling	ndltd-arizona.edu-oai-arizona.openrepository.com-10150-6230772017-04-12T03:00:35Z Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA Weldon, Carika Behm-Ansmant, Isabelle Hurley, Laurence H Burley, Glenn A Branlant, Christiane Eperon, Ian C Dominguez, Cyril College of Pharmacy and BIO5 Institute, University of Arizona University of Arizona Cancer Center RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions. 2016-11-07 Article Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA 2016, 13 (1):18 Nature Chemical Biology 1552-4450 1552-4469 27820800 10.1038/nchembio.2228 http://hdl.handle.net/10150/623077 http://arizona.openrepository.com/arizona/handle/10150/623077 Nature Chemical Biology en http://www.nature.com/doifinder/10.1038/nchembio.2228 Copyright © 2016, Rights Managed by Nature Publishing Group NATURE PUBLISHING GROUP
collection	NDLTD
language	en
sources	NDLTD
description	RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.
author2	College of Pharmacy and BIO5 Institute, University of Arizona
author_facet	College of Pharmacy and BIO5 Institute, University of Arizona Weldon, Carika Behm-Ansmant, Isabelle Hurley, Laurence H Burley, Glenn A Branlant, Christiane Eperon, Ian C Dominguez, Cyril
author	Weldon, Carika Behm-Ansmant, Isabelle Hurley, Laurence H Burley, Glenn A Branlant, Christiane Eperon, Ian C Dominguez, Cyril
spellingShingle	Weldon, Carika Behm-Ansmant, Isabelle Hurley, Laurence H Burley, Glenn A Branlant, Christiane Eperon, Ian C Dominguez, Cyril Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA
author_sort	Weldon, Carika
title	Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA
title_short	Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA
title_full	Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA
title_fullStr	Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA
title_full_unstemmed	Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA
title_sort	identification of g-quadruplexes in long functional rnas using 7-deazaguanine rna
publisher	NATURE PUBLISHING GROUP
publishDate	2016
url	http://hdl.handle.net/10150/623077 http://arizona.openrepository.com/arizona/handle/10150/623077
work_keys_str_mv	AT weldoncarika identificationofgquadruplexesinlongfunctionalrnasusing7deazaguaninerna AT behmansmantisabelle identificationofgquadruplexesinlongfunctionalrnasusing7deazaguaninerna AT hurleylaurenceh identificationofgquadruplexesinlongfunctionalrnasusing7deazaguaninerna AT burleyglenna identificationofgquadruplexesinlongfunctionalrnasusing7deazaguaninerna AT branlantchristiane identificationofgquadruplexesinlongfunctionalrnasusing7deazaguaninerna AT eperonianc identificationofgquadruplexesinlongfunctionalrnasusing7deazaguaninerna AT dominguezcyril identificationofgquadruplexesinlongfunctionalrnasusing7deazaguaninerna
_version_	1718437638330908672

Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA

Similar Items