Demonstration of a potent RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma based on an ellipticine derivative
Dominant-activating mutations in the RET (rear-ranged during transfection) proto-oncogene, which encodes a receptor tyrosine kinase, is often associated with the development of medullary thyroid carcinoma (MTC). The proximal promoter region of the RET gene consists of a guanine-rich sequence contain...
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| Language: | en |
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SPANDIDOS PUBL LTD
2017
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| Online Access: | http://hdl.handle.net/10150/624673 http://arizona.openrepository.com/arizona/handle/10150/624673 |