The MNK–eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain

The MNK–eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain

Injury-induced sensitization of nociceptors contributes to pain states and the development of chronic pain. Inhibiting activity-dependent mRNA translation through mechanistic target of rapamycin and mitogen-activated protein kinase (MAPK) pathways blocks the development of nociceptor sensitization....

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Bibliographic Details
Main Authors: Moy, Jamie K., Khoutorsky, Arkady, Asiedu, Marina N., Black, Bryan J., Kuhn, Jasper L., Barragán-Iglesias, Paulino, Megat, Salim, Burton, Michael D., Burgos-Vega, Carolina C., Melemedjian, Ohannes K., Boitano, Scott, Vagner, Josef, Gkogkas, Christos G., Pancrazio, Joseph J., Mogil, Jeffrey S., Dussor, Gregory, Sonenberg, Nahum, Price, Theodore J.
Other Authors: Univ Arizona, Collaborat Res Inst Bio5
Language:en
Published: SOC NEUROSCIENCE 2017
Subjects:
chronic pain
dorsal root ganglion
eIF4E
MNK1
MNK2
nociceptor
Online Access:http://hdl.handle.net/10150/625494
http://arizona.openrepository.com/arizona/handle/10150/625494

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http://hdl.handle.net/10150/625494
http://arizona.openrepository.com/arizona/handle/10150/625494

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