P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy

P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy

Salivary gland inflammation is a hallmark of Sjogren's syndrome (SS), a common autoimmune disease characterized by lymphocytic infiltration of the salivary gland and loss of saliva secretion, predominantly in women. The P2X7 receptor (P2X7R) is an ATP-gated nonselective cation channel that indu...

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Bibliographic Details
Main Authors: Khalafalla, Mahmoud G., Woods, Lucas T., Camden, Jean M., Khan, Aslam A., Limesand, Kirsten H., Petris, Michael J., Erb, Laurie, Weisman, Gary A.
Other Authors: Univ Arizona, Dept Nutr Sci
Language:en
Published: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 2017
Online Access:http://hdl.handle.net/10150/625978
http://arizona.openrepository.com/arizona/handle/10150/625978

Internet

http://hdl.handle.net/10150/625978
http://arizona.openrepository.com/arizona/handle/10150/625978

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