Controlling Depth of Cellular Quiescence by an Rb-E2F Network Switch

Controlling Depth of Cellular Quiescence by an Rb-E2F Network Switch

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Quiescence is a non-proliferative cellular state that is critical to tissue repair and regeneration. Although often described as the G0 phase, quiescence is not a single homogeneous state. As cells remain quiescent for longer durations, they move progressively deeper and display a reduced sensitivit...

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Bibliographic Details
Main Authors: Kwon, Jungeun Sarah, Everetts, Nicholas J., Wang, Xia, Wang, Weikang, Della Croce, Kimiko, Xing, Jianhua, Yao, Guang
Other Authors: Univ Arizona, Dept Mol & Cellular Biol
Language:en
Published: CELL PRESS 2017
Subjects:
cellular quiescence
quiescence depth
quiescence heterogeneity
cell cycle entry
cell proliferation
cell growth
Rb-E2F pathway
bistable switch
model simulation
activation threshold
Online Access:http://hdl.handle.net/10150/625987
http://arizona.openrepository.com/arizona/handle/10150/625987

Internet

http://hdl.handle.net/10150/625987
http://arizona.openrepository.com/arizona/handle/10150/625987

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