Chemical Genomics Approach Leads to the Identification of Hesperadin, an Aurora B Kinase Inhibitor, as a Broad-Spectrum Influenza Antiviral

Chemical Genomics Approach Leads to the Identification of Hesperadin, an Aurora B Kinase Inhibitor, as a Broad-Spectrum Influenza Antiviral

Influenza viruses are respiratory pathogens that are responsible for annual influenza epidemics and sporadic influenza pandemics. Oseltamivir (Tamiflu((R))) is currently the only FDA-approved oral drug that is available for the prevention and treatment of influenza virus infection. However, its narr...

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Bibliographic Details
Main Authors: Hu, Yanmei, Zhang, Jiantao, Musharrafieh, Rami, Hau, Raymond, Ma, Chunlong, Wang, Jun
Other Authors: Univ Arizona, Dept Pharmacol & Toxicol
Language:en
Published: MDPI AG 2017
Subjects:
influenza
broad-spectrum antiviral
host-targeting antiviral
hesperadin
drug resistance
combination therapy
aurora kinase
Online Access:http://hdl.handle.net/10150/626106
http://arizona.openrepository.com/arizona/handle/10150/626106

Internet

http://hdl.handle.net/10150/626106
http://arizona.openrepository.com/arizona/handle/10150/626106

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