The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles.
Sequestering of latent HIV in follicular helper T cells within B-cell follicles that largely exclude cytotoxic T cells is a major barrier to cellular immune-based approaches to eradicate HIV. Here, we show that the clinical-grade human interleukin-15 (IL-15) superagonist ALT-803 activates and redire...
Main Authors: | , , , , , , , , , , , , , , , , , , |
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Other Authors: | |
Language: | en |
Published: |
AMER SOC HEMATOLOGY
2018
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Online Access: | http://hdl.handle.net/10150/626600 http://arizona.openrepository.com/arizona/handle/10150/626600 |