The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles.

The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles.

Sequestering of latent HIV in follicular helper T cells within B-cell follicles that largely exclude cytotoxic T cells is a major barrier to cellular immune-based approaches to eradicate HIV. Here, we show that the clinical-grade human interleukin-15 (IL-15) superagonist ALT-803 activates and redire...

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Bibliographic Details
Main Authors: Webb, Gabriela M, Li, Shengbin, Mwakalundwa, Gwantwa, Folkvord, Joy M, Greene, Justin M, Reed, Jason S, Stanton, Jeffery J, Legasse, Alfred W, Hobbs, Theodore, Martin, Lauren D, Park, Byung S, Whitney, James B, Jeng, Emily K, Wong, Hing C, Nixon, Douglas F, Jones, R Brad, Connick, Elizabeth, Skinner, Pamela J, Sacha, Jonah B
Other Authors: Univ Arizona, Div Infect Dis
Language:en
Published: AMER SOC HEMATOLOGY 2018
Online Access:http://hdl.handle.net/10150/626600
http://arizona.openrepository.com/arizona/handle/10150/626600

Internet

http://hdl.handle.net/10150/626600
http://arizona.openrepository.com/arizona/handle/10150/626600

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