Atypical Opioid Interactions – Development of Selective Mu-Delta Heterodimer Antagonists, Clinical Opioids at Non-Mu Pain Targets and Endogenous Biased Signaling

Atypical Opioid Interactions – Development of Selective Mu-Delta Heterodimer Antagonists, Clinical Opioids at Non-Mu Pain Targets and Endogenous Biased Signaling

Most clinical opioids produce analgesia through the Mu Opioid Receptor (MOR) providing the only effective treatment for chronic pain patients. These studies explore three pre-clinical strategies to improve MOR analgesia and minimize side effects: 1) compounds that target G-protein Coupled Receptors...

Full description

Bibliographic Details
Main Author: Olson, Keith Mathew
Other Authors: Hruby, Victor J.
Language:en_US
Published: The University of Arizona. 2017
Subjects:
Bivalent
Delta Opioid Receptor
Functional Selectivity
MDOR Heterodimer
Mu Opioid Receptor
Opioid Signaling
Online Access:http://hdl.handle.net/10150/626669
http://arizona.openrepository.com/arizona/handle/10150/626669

Internet

http://hdl.handle.net/10150/626669
http://arizona.openrepository.com/arizona/handle/10150/626669

Similar Items