Changes in Sensitivity to the Effects of Atrazine on the Luteinizing Hormone Surge in Female Sprague-Dawley Rats after Repeated Daily Doses: Correlation with Liver Enzyme Expression

Changes in Sensitivity to the Effects of Atrazine on the Luteinizing Hormone Surge in Female Sprague-Dawley Rats after Repeated Daily Doses: Correlation with Liver Enzyme Expression

BackgroundAtrazine suppression of the LH surge slowly develops over time and peaks after 4 days; sensitivity to atrazine decreases after 8 or 14 days of dosing. Adaptation of the LH response was correlated with increased phase I and phase II liver enzyme activity/expression. MethodsThe effect of atr...

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Bibliographic Details
Main Authors: Breckenridge, Charles B., Foradori, Chad D., Sawhney Coder, Pragati, Simpkins, James W., Sielken, Robert L., Handa, Robert J.
Other Authors: Univ Arizona, Dept Basic Med Sci, Coll Med
Language:en
Published: WILEY 2018
Subjects:
LH surge
gavage
atrazine
sensitivity
adaptation
phase I metabolism
phase II metabolism
Online Access:http://hdl.handle.net/10150/627193
http://arizona.openrepository.com/arizona/handle/10150/627193

Internet

http://hdl.handle.net/10150/627193
http://arizona.openrepository.com/arizona/handle/10150/627193

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