Glycan-Cyanovirin-N Interactions and Designed WW Domains: Combining Experimental and Computational Studies

Glycan-Cyanovirin-N Interactions and Designed WW Domains: Combining Experimental and Computational Studies

abstract: Cyanovirin-N (CVN) is a cyanobacterial lectin with potent anti-HIV activity, mediated by binding to the N-linked oligosaccharide moiety of the envelope protein gp120. CVN offers a scaffold to develop multivalent carbohydrate-binding proteins with tunable specificities and affinities. I pre...

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Bibliographic Details
Other Authors: Woodrum, Brian William (Author)
Format: Doctoral Thesis
Language:English
Published: 2014
Subjects:
Biochemistry
Biophysics
BP-Dock
cyanovirin-N
HIV
protein design
WW domain
Online Access:http://hdl.handle.net/2286/R.I.25913

Internet

http://hdl.handle.net/2286/R.I.25913

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