Opening Chromatin and Improving CRISPR / Cas9 Editing
abstract: The research question explored in this thesis is how CRISPR mediated editing is influenced by artificially opened chromatin in cells. Closed chromatin poses a barrier to Cas9 binding and editing at target genes. Synthetic pioneer factors (PFs) are a promising new approach to artificially o...
| Other Authors: | |
|---|---|
| Format: | Dissertation |
| Language: | English |
| Published: |
2019
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/2286/R.I.53846 |